Two-step mechanism of J-domain action in driving Hsp70 function

J-domain proteins (JDPs), obligatory Hsp70 cochaperones, play critical roles in protein homeostasis. They promote key allosteric transitions that stabilize Hsp70 interaction with substrate polypeptides upon hydrolysis of its bound ATP. Although a recent crystal structure revealed the physical mode o...

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Enregistré dans:
Détails bibliographiques
Publié dans:PLoS Comput Biol
Auteurs principaux: Tomiczek, Bartlomiej, Delewski, Wojciech, Nierzwicki, Lukasz, Stolarska, Milena, Grochowina, Igor, Schilke, Brenda, Dutkiewicz, Rafal, Uzarska, Marta A., Ciesielski, Szymon J., Czub, Jacek, Craig, Elizabeth A., Marszalek, Jaroslaw
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2020
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7289447/
https://ncbi.nlm.nih.gov/pubmed/32479549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1007913
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