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Two-step mechanism of J-domain action in driving Hsp70 function
J-domain proteins (JDPs), obligatory Hsp70 cochaperones, play critical roles in protein homeostasis. They promote key allosteric transitions that stabilize Hsp70 interaction with substrate polypeptides upon hydrolysis of its bound ATP. Although a recent crystal structure revealed the physical mode o...
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| 發表在: | PLoS Comput Biol |
|---|---|
| Main Authors: | , , , , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Public Library of Science
2020
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7289447/ https://ncbi.nlm.nih.gov/pubmed/32479549 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1007913 |
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