Two-step mechanism of J-domain action in driving Hsp70 function

J-domain proteins (JDPs), obligatory Hsp70 cochaperones, play critical roles in protein homeostasis. They promote key allosteric transitions that stabilize Hsp70 interaction with substrate polypeptides upon hydrolysis of its bound ATP. Although a recent crystal structure revealed the physical mode o...

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Dades bibliogràfiques
Publicat a:PLoS Comput Biol
Autors principals: Tomiczek, Bartlomiej, Delewski, Wojciech, Nierzwicki, Lukasz, Stolarska, Milena, Grochowina, Igor, Schilke, Brenda, Dutkiewicz, Rafal, Uzarska, Marta A., Ciesielski, Szymon J., Czub, Jacek, Craig, Elizabeth A., Marszalek, Jaroslaw
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2020
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7289447/
https://ncbi.nlm.nih.gov/pubmed/32479549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1007913
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