Two-step mechanism of J-domain action in driving Hsp70 function

J-domain proteins (JDPs), obligatory Hsp70 cochaperones, play critical roles in protein homeostasis. They promote key allosteric transitions that stabilize Hsp70 interaction with substrate polypeptides upon hydrolysis of its bound ATP. Although a recent crystal structure revealed the physical mode o...

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Detalhes bibliográficos
Publicado no:PLoS Comput Biol
Main Authors: Tomiczek, Bartlomiej, Delewski, Wojciech, Nierzwicki, Lukasz, Stolarska, Milena, Grochowina, Igor, Schilke, Brenda, Dutkiewicz, Rafal, Uzarska, Marta A., Ciesielski, Szymon J., Czub, Jacek, Craig, Elizabeth A., Marszalek, Jaroslaw
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7289447/
https://ncbi.nlm.nih.gov/pubmed/32479549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1007913
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