Pervasive functional translation of non-canonical human open reading frames

Ribosome profiling has revealed pervasive but largely uncharacterized translation outside of canonical coding sequences (CDSs). Here, we exploit a systematic CRISPR-based screening strategy to identify hundreds of non-canonical CDSs that are essential for cellular growth and whose disruption elicit...

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Publicado no:Science
Main Authors: Chen, Jin, Brunner, Andreas-David, Cogan, J. Zachery, Nuñez, James K., Fields, Alexander P., Adamson, Britt, Itzhak, Daniel N., Li, Jason Y., Mann, Matthias, Leonetti, Manuel D., Weissman, Jonathan S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7289059/
https://ncbi.nlm.nih.gov/pubmed/32139545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aay0262
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