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Evaluating the Effects of Hinge Flexibility on the Solution Structure of Antibodies at Concentrated Conditions
Employing two different coarse-grained models, we evaluated the effect of intramolecular domain-domain distances and hinge flexibility on the general solution structure of antibodies (mAbs), within the context of protein-protein steric repulsion. These models explicitly account for the hinge region,...
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| Publicado no: | J Pharm Sci |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7288351/ https://ncbi.nlm.nih.gov/pubmed/30593783 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xphs.2018.12.013 |
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