Antiretroviral therapy concentrations differ in gut versus lymph node tissues and are associated with HIV viral transcription by a novel RT-ddPCR assay

BACKGROUND: The majority of HIV-infected cells during antiretroviral therapy (ART) persist in lymphoid tissues. Studies disagree on whether suboptimal tissue ART concentrations contribute to ongoing HIV replication during viral suppression. METHODS: We performed a cross-sectional study in virally-su...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Acquir Immune Defic Syndr
Prif Awduron: Lee, Sulggi A., Telwatte, Sushama, Hatano, Hiroyu, Kashuba, Angela D.M., Cottrell, Mackenzie L., Hoh, Rebecca, Liegler, Teri J., Stephenson, Sophie, Somsouk, Ma, Hunt, Peter W., Deeks, Steven G., Yukl, Steven, Savic, Radojka M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2020
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7286563/
https://ncbi.nlm.nih.gov/pubmed/32168200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAI.0000000000002287
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