Antiretroviral therapy concentrations differ in gut versus lymph node tissues and are associated with HIV viral transcription by a novel RT-ddPCR assay

BACKGROUND: The majority of HIV-infected cells during antiretroviral therapy (ART) persist in lymphoid tissues. Studies disagree on whether suboptimal tissue ART concentrations contribute to ongoing HIV replication during viral suppression. METHODS: We performed a cross-sectional study in virally-su...

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Detalhes bibliográficos
Publicado no:J Acquir Immune Defic Syndr
Main Authors: Lee, Sulggi A., Telwatte, Sushama, Hatano, Hiroyu, Kashuba, Angela D.M., Cottrell, Mackenzie L., Hoh, Rebecca, Liegler, Teri J., Stephenson, Sophie, Somsouk, Ma, Hunt, Peter W., Deeks, Steven G., Yukl, Steven, Savic, Radojka M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7286563/
https://ncbi.nlm.nih.gov/pubmed/32168200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAI.0000000000002287
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