Gut and blood differ in constitutive blocks to HIV transcription, suggesting tissue-specific differences in the mechanisms that govern HIV latency

Latently-infected CD4+ T cells are widely considered to be the major barrier to a cure for HIV. Much of our understanding of HIV latency comes from latency models and blood cells, but most HIV-infected cells reside in lymphoid tissues such as the gut. We hypothesized that tissue-specific environment...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Telwatte, Sushama, Lee, Sulggi, Somsouk, Ma, Hatano, Hiroyu, Baker, Christopher, Kaiser, Philipp, Kim, Peggy, Chen, Tsui-Hua, Milush, Jeffrey, Hunt, Peter W., Deeks, Steven G., Wong, Joseph K., Yukl, Steven A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6237391/
https://ncbi.nlm.nih.gov/pubmed/30440043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1007357
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