IFN-γ enhances cell-mediated cytotoxicity against keratinocytes via JAK2/STAT1 in lichen planus

Lichen planus (LP) is a chronic debilitating inflammatory disease of unknown etiology affecting the skin, nails, and mucosa, and is histologically characterized by dense infiltration of T cells and epidermal keratinocyte apoptosis. Using global transcriptomic profiling, we demonstrate that LP is cha...

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Detalhes bibliográficos
Publicado no:Sci Transl Med
Main Authors: Shao, Shuai, Tsoi, Lam C., Sarkar, Mrinal K., Xing, Xianying, Xue, Ke, Uppala, Ranjitha, Berthier, Celine C., Zeng, Chang, Patrick, Matthew, Billi, Allison C., Fullmer, Joseph, Beamer, Maria A, Perez-White, Bethany, Getsios, Spiro, Schuler, Andrew, Voorhees, John J., Choi, Sung, Harms, Paul, Kahlenberg, J. Michelle, Gudjonsson, Johann E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7285657/
https://ncbi.nlm.nih.gov/pubmed/31554739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aav7561
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