Loss of ARF/INK4A Promotes Liver Progenitor Cell Transformation Toward Tumorigenicity Supporting Their Role in Hepatocarcinogenesis

Liver progenitor cells (LPCs) contribute to liver regeneration during chronic damage and are implicated as cells of origin for liver cancers including hepatocellular carcinoma (HCC). The CDKN2A locus, which encodes the tumor suppressors alternate reading frame protein (ARF) and INK4A, was identified...

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Publicat a:Gene Expr
Autors principals: Strauss, Robyn P., Audsley, Katherine M., Passman, Adam M., van Vuuren, Joanne H., Finch-Edmondson, Megan L., Callus, Bernard A., Yeoh, George C.
Format: Artigo
Idioma:Inglês
Publicat: Cognizant Communication Corporation 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7284103/
https://ncbi.nlm.nih.gov/pubmed/32317048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3727/105221620X15874935364268
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