Loss of ARF/INK4A Promotes Liver Progenitor Cell Transformation Toward Tumorigenicity Supporting Their Role in Hepatocarcinogenesis

Liver progenitor cells (LPCs) contribute to liver regeneration during chronic damage and are implicated as cells of origin for liver cancers including hepatocellular carcinoma (HCC). The CDKN2A locus, which encodes the tumor suppressors alternate reading frame protein (ARF) and INK4A, was identified...

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Publicado no:Gene Expr
Main Authors: Strauss, Robyn P., Audsley, Katherine M., Passman, Adam M., van Vuuren, Joanne H., Finch-Edmondson, Megan L., Callus, Bernard A., Yeoh, George C.
Formato: Artigo
Idioma:Inglês
Publicado em: Cognizant Communication Corporation 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7284103/
https://ncbi.nlm.nih.gov/pubmed/32317048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3727/105221620X15874935364268
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