Sub-Cellular Localisation Studies May Spuriously Detect the Yes-Associated Protein, YAP, in Nucleoli Leading to Potentially Invalid Conclusions of Its Function

The Yes-associated protein (YAP) is a potent transcriptional co-activator that functions as a nuclear effector of the Hippo signaling pathway. YAP is oncogenic and its activity is linked to its cellular abundance and nuclear localisation. Activation of the Hippo pathway restricts YAP nuclear entry v...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Finch, Megan L., Passman, Adam M., Strauss, Robyn P., Yeoh, George C., Callus, Bernard A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4320119/
https://ncbi.nlm.nih.gov/pubmed/25658431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0114813
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