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Format and geometries matter: Structure-based design defines the functionality of bispecific antibodies

Multispecific antibodies can be generated in different formats. More than two decades of R&D in the field of bispecific antibody engineering revealed that the design and choice of format can have a profound impact on the antibody functionality. This holds in particular true for entities that eli...

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Detalhes bibliográficos
Publicado no:Comput Struct Biotechnol J
Main Authors: Dickopf, Steffen, Georges, Guy J., Brinkmann, Ulrich
Formato: Artigo
Idioma:Inglês
Publicado em: Research Network of Computational and Structural Biotechnology 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7283971/
https://ncbi.nlm.nih.gov/pubmed/32542108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.csbj.2020.05.006
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