The Contorsbody, an antibody format for agonism: Design, structure, and function

The careful design of the antibody architecture is becoming more and more important, especially when the purpose is agonism. We present the design of a novel antibody format that is able to promote receptor dimerization and induce signal transduction resulting in cell proliferation. Mono-specific bi...

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Detalhes bibliográficos
Publicado no:Comput Struct Biotechnol J
Main Authors: Georges, Guy J., Dengl, Stefan, Bujotzek, Alexander, Hesse, Friederike, Fischer, Jens A.A., Gärtner, Achim, Benz, Jörg, Lauer, Matthias E., Ringler, Philippe, Stahlberg, Henning, Plath, Friederike, Brinkmann, Ulrich, Imhof-Jung, Sabine
Formato: Artigo
Idioma:Inglês
Publicado em: Research Network of Computational and Structural Biotechnology 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7283085/
https://ncbi.nlm.nih.gov/pubmed/32542107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.csbj.2020.05.007
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