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Challenges and opportunities for engineering assembly-line polyketide biosynthesis in Escherichia coli

Assembly-line polyketide synthases generate natural products that have led to many live-saving drugs. The use of E. coli as a heterologous host for reconstituting these enormous and complex enzymatic machines has and will continue to be a critical strategy for understanding them. Here, we concisely...

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Publicado en:Metab Eng Commun
Autores principales: Yuet, Kai P., Khosla, Chaitan
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2019
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7283498/
https://ncbi.nlm.nih.gov/pubmed/32547924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mec.2019.e00106
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