Modulation of dopamine D(1) receptors via histamine H(3) receptors is a novel therapeutic target for Huntington's disease

Early Huntington’s disease (HD) include over-activation of dopamine D(1) receptors (D(1)R), producing an imbalance in dopaminergic neurotransmission and cell death. To reduce D(1)R over-activation, we present a strategy based on targeting complexes of D(1)R and histamine H(3) receptors (H(3)R). Usin...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Moreno-Delgado, David, Puigdellívol, Mar, Moreno, Estefanía, Rodríguez-Ruiz, Mar, Botta, Joaquín, Gasperini, Paola, Chiarlone, Anna, Howell, Lesley A, Scarselli, Marco, Casadó, Vicent, Cortés, Antoni, Ferré, Sergi, Guzmán, Manuel, Lluís, Carmen, Alberch, Jordi, Canela, Enric I, Ginés, Silvia, McCormick, Peter J
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2020
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7282811/
https://ncbi.nlm.nih.gov/pubmed/32513388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.51093
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