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Zalypsis (PM00104) is a potent inducer of γ-H2AX foci and reveals the importance of trabectedin’s C-ring for transcription-coupled repair inhibition
Zalypsis(®) (PM00104) is a novel tetrahydroisoquinoline alkaloid related to trabectedin (Ecteinascidin 743; Et743). Et743 and PM00104 have similar A- and B-rings but differ in their C-rings. The present study demonstrates that Et743 and PM00104 differ in at least two ways: in their DNA binding prope...
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| 發表在: | Mol Cancer Ther |
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| Main Authors: | , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2009
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7282704/ https://ncbi.nlm.nih.gov/pubmed/19584237 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-09-0336 |
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