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Zalypsis (PM00104) is a potent inducer of γ-H2AX foci and reveals the importance of trabectedin’s C-ring for transcription-coupled repair inhibition

Zalypsis(®) (PM00104) is a novel tetrahydroisoquinoline alkaloid related to trabectedin (Ecteinascidin 743; Et743). Et743 and PM00104 have similar A- and B-rings but differ in their C-rings. The present study demonstrates that Et743 and PM00104 differ in at least two ways: in their DNA binding prope...

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發表在:Mol Cancer Ther
Main Authors: Guirouilh-Barbat, Josée, Antony, Smitha, Pommier, Yves
格式: Artigo
語言:Inglês
出版: 2009
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7282704/
https://ncbi.nlm.nih.gov/pubmed/19584237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-09-0336
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