Peroxynitrite promotes serine-62 phosphorylation-dependent stabilization of the oncoprotein c-Myc

Stabilization of c-Myc oncoprotein is dependent on post-translational modifications, especially its phosphorylation at serine-62 (S62), which enhances its tumorigenic potential. Herein we report that increase in intracellular superoxide induces phospho-stabilization and activation of c-Myc in cancer...

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Bibliografische gegevens
Gepubliceerd in:Redox Biol
Hoofdauteurs: Raman, Deepika, Chong, Stephen J.F., Iskandar, Kartini, Hirpara, Jayshree L., Pervaiz, Shazib
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Elsevier 2020
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Research Paper
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7280771/
https://ncbi.nlm.nih.gov/pubmed/32512497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2020.101587
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