Serine-70 phosphorylated Bcl-2 prevents oxidative stress-induced DNA damage by modulating the mitochondrial redox metabolism

Bcl-2 phosphorylation at serine-70 (S70pBcl2) confers resistance against drug-induced apoptosis. Nevertheless, its specific mechanism in driving drug-resistance remains unclear. We present evidence that S70pBcl2 promotes cancer cell survival by acting as a redox sensor and modulator to prevent oxida...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Chong, Stephen Jun Fei, Iskandar, Kartini, Lai, Jolin Xiao Hui, Qu, Jianhua, Raman, Deepika, Valentin, Rebecca, Herbaux, Charles, Collins, Mary, Low, Ivan Cherh Chiet, Loh, Thomas, Davids, Matthew, Pervaiz, Shazib
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Genome Integrity, Repair and Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7736805/
https://ncbi.nlm.nih.gov/pubmed/33245769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa1110
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