Serine-70 phosphorylated Bcl-2 prevents oxidative stress-induced DNA damage by modulating the mitochondrial redox metabolism

Bcl-2 phosphorylation at serine-70 (S70pBcl2) confers resistance against drug-induced apoptosis. Nevertheless, its specific mechanism in driving drug-resistance remains unclear. We present evidence that S70pBcl2 promotes cancer cell survival by acting as a redox sensor and modulator to prevent oxida...

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Detaylı Bibliyografya
Yayımlandı:Nucleic Acids Res
Asıl Yazarlar: Chong, Stephen Jun Fei, Iskandar, Kartini, Lai, Jolin Xiao Hui, Qu, Jianhua, Raman, Deepika, Valentin, Rebecca, Herbaux, Charles, Collins, Mary, Low, Ivan Cherh Chiet, Loh, Thomas, Davids, Matthew, Pervaiz, Shazib
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2020
Konular:
Genome Integrity, Repair and Replication
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7736805/
https://ncbi.nlm.nih.gov/pubmed/33245769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa1110
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