Kinase inhibition of G2019S-LRRK2 enhances autolysosome formation and function to reduce endogenous alpha-synuclein intracellular inclusions

The Parkinson’s disease (PD)-associated kinase Leucine-Rich Repeat Kinase 2 (LRRK2) is a crucial modulator of the autophagy-lysosome pathway, but unclarity exists on the precise mechanics of its role and the direction of this modulation. In particular, LRRK2 is involved in the degradation of patholo...

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Pubblicato in:Cell Death Discov
Autori principali: Obergasteiger, Julia, Frapporti, Giulia, Lamonaca, Giulia, Pizzi, Sara, Picard, Anne, Lavdas, Alexandros A., Pischedda, Francesca, Piccoli, Giovanni, Hilfiker, Sabine, Lobbestael, Evy, Baekelandt, Veerle, Hicks, Andrew A., Corti, Corrado, Pramstaller, Peter P., Volta, Mattia
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7280235/
https://ncbi.nlm.nih.gov/pubmed/32550012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41420-020-0279-y
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