Intraperitoneal injection of IFN-γ restores microglial autophagy, promotes amyloid-β clearance and improves cognition in APP/PS1 mice

Autophagy is a major self-degradative process that maintains cellular homeostasis and function in mammalian cells. Autophagic dysfunction occurs in the early pathogenesis of Alzheimer’s disease (AD) and directly regulates amyloid-β (Aβ) metabolism. Although it has been proven that the cytokine IFN-γ...

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Publicado en:Cell Death Dis
Autores principales: He, Zitian, Yang, Yunjie, Xing, Zhiwei, Zuo, Zejie, Wang, Rui, Gu, Huaiyu, Qi, Fangfang, Yao, Zhibin
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7280212/
https://ncbi.nlm.nih.gov/pubmed/32514180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-2644-4
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