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Klotho overexpression improves amyloid‐β clearance and cognition in the APP/PS1 mouse model of Alzheimer's disease

Alzheimer's disease (AD) is the most prevalent type of dementia, characterized by the presence of amyloid‐β (Aβ) plaques. We previously reported that Klotho lowered Aβ levels in the brain and protected against cognitive deficits in amyloid precursor protein/presenilin 1(APP/PS1) mice. However,...

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Detalhes bibliográficos
Publicado no:Aging Cell
Main Authors: Zhao, Yue, Zeng, Chen‐Ye, Li, Xiao‐Hong, Yang, Ting‐Ting, Kuang, Xi, Du, Jun‐Rong
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7576297/
https://ncbi.nlm.nih.gov/pubmed/32964663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.13239
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