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Inhibition of fatty acid amide hydrolase in the CNS prevents and reverses morphine tolerance in male and female mice

BACKGROUND AND PURPOSE: Fatty acid amide hydrolase (FAAH) is an intracellular serine amidase that terminates the signalling of various lipid messengers involved in pain regulation, including anandamide and palmitoylethanolamide. Here, we investigated the effects of pharmacological or genetic FAAH re...

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Vydáno v:Br J Pharmacol
Hlavní autoři: Fotio, Yannick, Palese, Francesca, Guaman Tipan, Pablo, Ahmed, Faizy, Piomelli, Daniele
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7280000/
https://ncbi.nlm.nih.gov/pubmed/32077093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.15031
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