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Glutamine-451 Confers Sensitivity to Oxidative Inhibition and Heme-Thiolate Sulfenylation of Cytochrome P450 4B1
Human cytochrome P450 (P450) Family 4 enzymes are involved in the metabolism of fatty acids and the bioactivation of carcinogenic arylamines and toxic natural products, e.g. 4-ipomeanol. These and other drug metabolizing P450s are redox sensitive, showing a loss of activity resulting from preincubat...
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| Publicado no: | Chem Res Toxicol |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7279892/ https://ncbi.nlm.nih.gov/pubmed/30701961 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.chemrestox.8b00353 |
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