Restoration of miR-340 controls pancreatic cancer cell CD47 expression to promote macrophage phagocytosis and enhance antitumor immunity

BACKGROUND: Immune checkpoint blockade has emerged as a potential cancer immunotherapy. The “don’t eat me” signal CD47 in cancer cells binds signal regulatory protein-α on macrophages and prevents their phagocytosis. The role of miR-340 in pancreatic ductal adenocarcinoma (PDAC), especially in tumor...

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Udgivet i:J Immunother Cancer
Main Authors: Xi, Qing, Zhang, Jieyou, Yang, Guangze, Zhang, Lijuan, Chen, Ying, Wang, Chengzhi, Zhang, Zimu, Guo, Xiangdong, Zhao, Jingyi, Xue, Zhenyi, Li, Yan, Zhang, Qi, Da, Yurong, Liu, Li, Yao, Zhi, Zhang, Rongxin
Format: Artigo
Sprog:Inglês
Udgivet: BMJ Publishing Group 2020
Fag:
Basic Tumor Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7279671/
https://ncbi.nlm.nih.gov/pubmed/32503944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2019-000253
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