CD47 blocking antibodies restore phagocytosis and prevent atherosclerosis

Atherosclerosis is the disease process underlying heart attack and stroke(1). Advanced lesions at risk for rupture are characterized by the pathological accumulation of diseased vascular cells and apoptotic cellular debris(2). Why these cells are not cleared remains unknown(3). Here we show that ath...

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Publicado no:Nature
Main Authors: Kojima, Yoko, Volkmer, Jens-Peter, McKenna, Kelly, Civelek, Mete, Lusis, A. Jake, Miller, Clint, Direnzo, Daniel, Nanda, Vivek, Ye, Jianqin, Connolly, Andrew, Schadt, Eric, Quertermous, Thomas, Betancur, Paola, Maegdefessel, Lars, Perisic, Ljubica, Hedin, Ulf, Weissman, Irv, Leeper, Nicholas J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4980260/
https://ncbi.nlm.nih.gov/pubmed/27437576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature18935
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