CD47 blocking antibodies restore phagocytosis and prevent atherosclerosis

Atherosclerosis is the disease process underlying heart attack and stroke(1). Advanced lesions at risk for rupture are characterized by the pathological accumulation of diseased vascular cells and apoptotic cellular debris(2). Why these cells are not cleared remains unknown(3). Here we show that ath...

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Publicado en:Nature
Autores principales: Kojima, Yoko, Volkmer, Jens-Peter, McKenna, Kelly, Civelek, Mete, Lusis, A. Jake, Miller, Clint, Direnzo, Daniel, Nanda, Vivek, Ye, Jianqin, Connolly, Andrew, Schadt, Eric, Quertermous, Thomas, Betancur, Paola, Maegdefessel, Lars, Perisic, Ljubica, Hedin, Ulf, Weissman, Irv, Leeper, Nicholas J.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4980260/
https://ncbi.nlm.nih.gov/pubmed/27437576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature18935
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