Targeted Amino Acid Substitution Overcomes Scale-Up Challenges with the Human C5a-Derived Decapeptide Immunostimulant EP67

EP67 is a second-generation, human C5a-derived decapeptide agonist of C5a Receptor 1 (C5aR1/CD88) that selectively activates mononuclear phagocytes over neutrophils to potentiate protective innate and adaptive immune responses while potentially minimizing neutrophil-mediated toxicity. Pro(7) and N-m...

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Veröffentlicht in:ACS Infect Dis
Hauptverfasser: Alshammari, Abdulraman M., Smith, D. David, Parriott, Jake, Stewart, Jason P., Curran, Stephen M., McCulloh, Russell J., Barry, Peter A., Iyer, Smita S., Palermo, Nicholas, Phillips, Joy A., Dong, Yuxiang, Ronning, Donald R., Vennerstrom, Jonathan L., Sanderson, Sam D., Vetro, Joseph A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7279522/
https://ncbi.nlm.nih.gov/pubmed/32233506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.0c00005
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