Surface conjugation of EP67 to biodegradable nanoparticles increases the generation of long-lived mucosal and systemic memory T-cells by encapsulated protein vaccine after respiratory immunization and subsequent T-cell-mediated protection against respiratory infection

Encapsulation of protein vaccines in biodegradable nanoparticles (NP) increases T-cell expansion after mucosal immunization but requires incorporating a suitable immunostimulant to increase long-lived memory T-cells. EP67 is a clinically viable, host-derived peptide agonist of the C5a receptor that...

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Publicado no:Int J Pharm
Main Authors: Tallapaka, Shailendra B., Karuturi, Bala V. K., Yeapuri, Pravin, Curran, Stephen M., Sonawane, Yogesh A., Phillips, Joy A., Smith, D. David, Sanderson, Sam D., Vetro, Joseph A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6935512/
https://ncbi.nlm.nih.gov/pubmed/31077762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijpharm.2019.05.012
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