Dual Target Ligands with 4-tert-Butylphenoxy Scaffold as Histamine H(3) Receptor Antagonists and Monoamine Oxidase B Inhibitors

Dual target ligands are a promising concept for the treatment of Parkinson’s disease (PD). A combination of monoamine oxidase B (MAO B) inhibition with histamine H(3) receptor (H(3)R) antagonism could have positive effects on dopamine regulation. Thus, a series of twenty-seven 4-tert-butylphenoxyalk...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Łażewska, Dorota, Olejarz-Maciej, Agnieszka, Reiner, David, Kaleta, Maria, Latacz, Gniewomir, Zygmunt, Małgorzata, Doroz-Płonka, Agata, Karcz, Tadeusz, Frank, Annika, Stark, Holger, Kieć-Kononowicz, Katarzyna
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7279487/
https://ncbi.nlm.nih.gov/pubmed/32408504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21103411
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