Brain Protease Activated Receptor 1 Pathway: A Therapeutic Target in the Superoxide Dismutase 1 (SOD1) Mouse Model of Amyotrophic Lateral Sclerosis

Glia cells are involved in upper motor neuron degeneration in amyotrophic lateral sclerosis (ALS). Protease activated receptor 1 (PAR1) pathway is related to brain pathologies. Brain PAR1 is located on peri-synaptic astrocytes, adjacent to pyramidal motor neurons, suggesting possible involvement in...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Shavit-Stein, Efrat, Abu Rahal, Ihab, Bushi, Doron, Gera, Orna, Sharon, Roni, Gofrit, Shany G., Pollak, Lea, Mindel, Kate, Maggio, Nicola, Kloog, Yoel, Chapman, Joab, Dori, Amir
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7279358/
https://ncbi.nlm.nih.gov/pubmed/32408605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21103419
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