EDEM1 Drives Misfolded Protein Degradation via ERAD and Exploits ER-Phagy as Back-Up Mechanism When ERAD Is Impaired

Endoplasmic reticulum (ER)-associated degradation (ERAD) is the main mechanism of targeting ER proteins for degradation to maintain homeostasis, and perturbations of ERAD lead to pathological conditions. ER-degradation enhancing α-mannosidase-like (EDEM1) was proposed to extract terminally misfolded...

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Vydáno v:Int J Mol Sci
Hlavní autoři: Chiritoiu, Marioara, Chiritoiu, Gabriela N., Munteanu, Cristian V. A., Pastrama, Florin, Ivessa, N. Erwin, Petrescu, Stefana M.
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2020
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7279049/
https://ncbi.nlm.nih.gov/pubmed/32423001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21103468
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