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The GTPase Rab27b regulates the release, autophagic clearance, and toxicity of α-synuclein
α-Synuclein (αsyn) is the primary component of proteinaceous aggregates termed Lewy bodies that pathologically define synucleinopathies including Parkinson's disease (PD) and dementia with Lewy bodies (DLB). αsyn is hypothesized to spread through the brain in a prion-like fashion by misfolded p...
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| Publié dans: | J Biol Chem |
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| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Biochemistry and Molecular Biology
2020
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7278354/ https://ncbi.nlm.nih.gov/pubmed/32350025 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.013337 |
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