Mutual inhibition between Prkd2 and Bcl6 controls T follicular helper cell differentiation

T follicular helper cells (TFH) participate in germinal center (GC) development and are necessary for B cell production of high affinity, isotype switched antibodies. In a forward genetic screen we identified a missense mutation in Prkd2, encoding the serine/threonine kinase protein kinase D2, which...

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Publicado no:Sci Immunol
Main Authors: Misawa, Takuma, SoRelle, Jeffrey A., Choi, Jin Huk, Yue, Tao, Wang, Kuan-wen, McAlpine, William, Wang, Jianhui, Liu, Aijie, Tabeta, Koichi, Turer, Emre, Evers, Bret, Nair-Gill, Evan, Poddar, Subhajit, Su, Lijing, Ou, Feiya, Yu, Liyang, Russell, Jamie, Ludwig, Sara, Zhan, Xiaoming, Hildebrand, Sara, Li, Xiaohong, Tang, Miao, Murray, Anne R., Moresco, Eva Marie Y., Beutler, Bruce
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7278039/
https://ncbi.nlm.nih.gov/pubmed/31980486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciimmunol.aaz0085
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