Pharmacokinetics of Lusutrombopag, a Novel Thrombopoietin Receptor Agonist, in Rats by UPLC-MS/MS

Lusutrombopag is a second oral thrombopoietin (TPO) receptor agonist that selectively acts on human TPO receptors. In the study, UPLC-MS/MS was used to establish a selective and sensitive method to determine lusutrombopag with poziotinib as IS (internal standard) in rat plasma. Samples were prepared...

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Veröffentlicht in:Int J Anal Chem
Hauptverfasser: Wang, Bo, Chen, Feifei, Zhou, Quan, Zhou, Yunfang, Meng, Deru, Geng, Peiwu, Hua, Ailian, Ji, Weiping, Wang, Changxiong, Wang, Shuanghu, Hu, Liming
Format: Artigo
Sprache:Inglês
Veröffentlicht: Hindawi 2020
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7277053/
https://ncbi.nlm.nih.gov/pubmed/32550846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2020/7290470
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