Timing of antiviral treatment initiation is critical to reduce SARS-CoV-2 viral load

We modeled the viral dynamics of 13 untreated patients infected with SARS-CoV-2 to infer viral growth parameters and predict the effects of antiviral treatments. In order to reduce peak viral load by more than 2 logs, drug efficacy needs to be greater than 80% if treatment is administered after symp...

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Detalhes bibliográficos
Publicado no:medRxiv
Main Authors: Gonçalves, Antonio, Bertrand, Julie, Ke, Ruian, Comets, Emmanuelle, de Lamballerie, Xavier, Malvy, Denis, Pizzorno, Andrés, Terrier, Olivier, Calatrava, Manuel Rosa, Mentré, France, Smith, Patrick, Perelson, Alan S, Guedj, Jérémie
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7276997/
https://ncbi.nlm.nih.gov/pubmed/32511641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.04.04.20047886
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