Inhibition of human immunodeficiency virus type 1 by niclosamide through mTORC1 inhibition

Niclosamide has been known to inhibit a number of pH-dependent viruses via the neutralization of endosomal acidic pH. It has also been shown to disrupt the mTORC1 signaling pathway. The replication of many viruses requires mTORC1 activation. Here, we investigated the inhibitory activity of niclosami...

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Pubblicato in:Heliyon
Autori principali: Niyomdecha, Nattamon, Suptawiwat, Ornpreya, Boonarkart, Chompunuch, Jitobaom, Kunlakunya, Auewarakul, Prasert
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7276449/
https://ncbi.nlm.nih.gov/pubmed/32529067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.heliyon.2020.e04050
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