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Joint Analysis of Single Cell and Bulk Tissue Sequencing Data to Infer Intra-Tumor Heterogeneity
Many computational methods have been developed to discern intratumor heterogeneity (ITH) using DNA sequence data from bulk tumor samples. These methods share an assumption that two mutations arise from the same subclone if they have similar mutant allele-frequencies (MAFs), and thus it is difficult...
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| Publicado no: | Biometrics |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7275921/ https://ncbi.nlm.nih.gov/pubmed/31813161 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/biom.13198 |
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