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Joint Analysis of Single Cell and Bulk Tissue Sequencing Data to Infer Intra-Tumor Heterogeneity

Many computational methods have been developed to discern intratumor heterogeneity (ITH) using DNA sequence data from bulk tumor samples. These methods share an assumption that two mutations arise from the same subclone if they have similar mutant allele-frequencies (MAFs), and thus it is difficult...

詳細記述

保存先:
書誌詳細
出版年:Biometrics
主要な著者: Sun, Wei, Jin, Chong, Gelfond, Jonathan A., Chen, Ming-Hui, Ibrahim, Joseph G.
フォーマット: Artigo
言語:Inglês
出版事項: 2019
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7275921/
https://ncbi.nlm.nih.gov/pubmed/31813161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/biom.13198
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