NAD(+) Controls Circadian Reprogramming Through PER2 Nuclear Translocation to Counter Aging

Disrupted sleep-wake and molecular circadian rhythms are a feature of aging associated with metabolic disease and reduced levels of NAD(+), yet whether changes in nucleotide metabolism control circadian behavioral and genomic rhythms remains unknown. Here we reveal that supplementation with the NAD(...

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Udgivet i:Mol Cell
Main Authors: Levine, Daniel C, Hong, Heekyung, Weidemann, Benjamin J, Ramsey, Kathryn M, Affinati, Alison H, Schmidt, Mark S, Cedernaes, Jonathan, Omura, Chiaki, Braun, Rosemary, Lee, Choogon, Brenner, Charles, Peek, Clara Bien, Bass, Joseph
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7275919/
https://ncbi.nlm.nih.gov/pubmed/32369735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2020.04.010
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