Circadian Clock Feedback Cycle Through NAMPT-Mediated NAD(+) Biosynthesis

The circadian clock is encoded by a transcription-translation feedback loop that synchronizes behavior and metabolism with the light-dark cycle. Here we report that both the rate-limiting enzyme in mammalian NAD(+) biosynthesis, nicotinamide phosphoribosyltransferase (NAMPT), and levels of NAD(+), d...

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Detalhes bibliográficos
Main Authors: Ramsey, Kathryn Moynihan, Yoshino, Jun, Brace, Cynthia S., Abrassart, Dana, Kobayashi, Yumiko, Marcheva, Biliana, Hong, Hee-Kyung, Chong, Jason L., Buhr, Ethan D., Lee, Choogon, Takahashi, Joseph S., Imai, Shin-ichiro, Bass, Joseph
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2738420/
https://ncbi.nlm.nih.gov/pubmed/19299583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1171641
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