Circadian Clock NAD(+) Cycle Drives Mitochondrial Oxidative Metabolism in Mice

Circadian clocks are self-sustained cellular oscillators that synchronize oxidative and reductive cycles in anticipation of the solar cycle. We found that the clock transcription feedback loop produces cycles of nicotinamide adenine dinucleotide (NAD(+)) biosynthesis, adenosine triphosphate producti...

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Autori principali: Peek, Clara Bien, Affinati, Alison H., Ramsey, Kathryn Moynihan, Kuo, Hsin-Yu, Yu, Wei, Sena, Laura A., Ilkayeva, Olga, Marcheva, Biliana, Kobayashi, Yumiko, Omura, Chiaki, Levine, Daniel C., Bacsik, David J., Gius, David, Newgard, Christopher B., Goetzman, Eric, Chandel, Navdeep S., Denu, John M., Mrksich, Milan, Bass, Joseph
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3963134/
https://ncbi.nlm.nih.gov/pubmed/24051248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1243417
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