Circadian Clock NAD(+) Cycle Drives Mitochondrial Oxidative Metabolism in Mice

Circadian clocks are self-sustained cellular oscillators that synchronize oxidative and reductive cycles in anticipation of the solar cycle. We found that the clock transcription feedback loop produces cycles of nicotinamide adenine dinucleotide (NAD(+)) biosynthesis, adenosine triphosphate producti...

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Bibliographic Details
Main Authors: Peek, Clara Bien, Affinati, Alison H., Ramsey, Kathryn Moynihan, Kuo, Hsin-Yu, Yu, Wei, Sena, Laura A., Ilkayeva, Olga, Marcheva, Biliana, Kobayashi, Yumiko, Omura, Chiaki, Levine, Daniel C., Bacsik, David J., Gius, David, Newgard, Christopher B., Goetzman, Eric, Chandel, Navdeep S., Denu, John M., Mrksich, Milan, Bass, Joseph
Format: Artigo
Language:Inglês
Published: 2013
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3963134/
https://ncbi.nlm.nih.gov/pubmed/24051248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1243417
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