A Metformin-Responsive Metabolic Pathway controls distinct steps in gastric progenitor fate decisions and maturation

Cellular metabolism plays important functions in dictating stem cell behaviors, although its role in stomach epithelial homeostasis has not been evaluated in depth. Here we show that the energy sensor AMP Kinase (AMPK) governs gastric epithelial progenitor differentiation. Administering the AMPK act...

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Bibliografski detalji
Izdano u:Cell Stem Cell
Glavni autori: Miao, Zhi-Feng, Adkins-Threats, Mahliyah, Burclaff, Joseph R., Osaki, Luciana H., Sun, Jing-Xu, Kefalov, Yan, He, Zheng, Wang, Zhen-Ning, Mills, Jason C.
Format: Artigo
Jezik:Inglês
Izdano: 2020
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7275895/
https://ncbi.nlm.nih.gov/pubmed/32243780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2020.03.006
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