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DDIT4 licenses only healthy cells to proliferate during injury-induced metaplasia
BACKGROUND AND AIMS: In stomach, metaplasia can arise from differentiated chief cells that become mitotic via paligenosis, a stepwise program. In paligenosis, mitosis initiation requires reactivation of the cellular energy hub mTORC1 after initial mTORC1 suppression by DNA damage induced transcript...
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| Publicado no: | Gastroenterology |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7857017/ https://ncbi.nlm.nih.gov/pubmed/32956680 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2020.09.016 |
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