DDIT4 licenses only healthy cells to proliferate during injury-induced metaplasia

BACKGROUND AND AIMS: In stomach, metaplasia can arise from differentiated chief cells that become mitotic via paligenosis, a stepwise program. In paligenosis, mitosis initiation requires reactivation of the cellular energy hub mTORC1 after initial mTORC1 suppression by DNA damage induced transcript...

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Publicado en:Gastroenterology
Autores principales: Miao, Zhi-Feng, Sun, Jing-Xu, Adkins-Threats, Mahliyah, Pang, Min-Jiao, Zhao, Jun-Hua, Wang, Xin, Tang, Kai-Wen, Wang, Zhen-Ning, Mills, Jason C.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7857017/
https://ncbi.nlm.nih.gov/pubmed/32956680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2020.09.016
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