Analysis of RAS protein interactions in living cells reveals a mechanism for pan-RAS depletion by membrane-targeted RAS binders

HRAS, NRAS, and KRAS4A/KRAS4B comprise the RAS family of small GTPases that regulate signaling pathways controlling cell proliferation, differentiation, and survival. RAS pathway abnormalities cause developmental disorders and cancers. We found that KRAS4B colocalizes on the cell membrane with other...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Li, Yao-Cheng, Lytle, Nikki K., Gammon, Seth T., Wang, Luke, Hayes, Tikvah K., Sutton, Margie N., Bast, Robert C., Der, Channing J., Piwnica-Worms, David, McCormick, Frank, Wahl, Geoffrey M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7275768/
https://ncbi.nlm.nih.gov/pubmed/32424096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2000848117
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