Activin-A limits Th17 pathogenicity and autoimmune neuroinflammation via CD39 and CD73 ectonucleotidases and Hif1-α–dependent pathways

In multiple sclerosis (MS), Th17 cells are critical drivers of autoimmune central nervous system (CNS) inflammation and demyelination. Th17 cells exhibit functional heterogeneity fostering both pathogenic and nonpathogenic, tissue-protective functions. Still, the factors that control Th17 pathogenic...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Morianos, Ioannis, Trochoutsou, Aikaterini I., Papadopoulou, Gina, Semitekolou, Maria, Banos, Aggelos, Konstantopoulos, Dimitris, Manousopoulou, Antigoni, Kapasa, Maria, Wei, Ping, Lomenick, Brett, Belaidi, Elise, Kalamatas, Themis, Karageorgiou, Klinta, Doskas, Triantafyllos, Sallusto, Federica, Pan, Fan, Garbis, Spiros D., Quintana, Francisco J., Xanthou, Georgina
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7275751/
https://ncbi.nlm.nih.gov/pubmed/32409602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1918196117
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