Activin-A co-opts IRF4 and AhR signaling to induce human regulatory T cells that restrain asthmatic responses

Type 1 regulatory T (Tr1) cells play a pivotal role in restraining human T-cell responses toward environmental allergens and protecting against allergic diseases. Still, the precise molecular cues that underlie their transcriptional and functional specification remain elusive. Here, we show that the...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Tousa, Sofia, Semitekolou, Maria, Morianos, Ioannis, Banos, Aggelos, Trochoutsou, Aikaterini I., Brodie, Tess M., Poulos, Nikolaos, Samitas, Konstantinos, Kapasa, Maria, Konstantopoulos, Dimitris, Paraskevopoulos, Giannis, Gaga, Mina, Hawrylowicz, Catherine M., Sallusto, Federica, Xanthou, Georgina
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5389328/
https://ncbi.nlm.nih.gov/pubmed/28320933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1616942114
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