CTCF loss mediates unique DNA hypermethylation landscapes in human cancers

BACKGROUND: The chromatin insulator CCCTC-binding factor (CTCF) displays tissue-specific DNA binding sites that regulate transcription and chromatin organization. Despite evidence linking CTCF to the protection of epigenetic states through barrier insulation, the impact of CTCF loss on genome-wide D...

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Detalhes bibliográficos
Publicado no:Clin Epigenetics
Main Authors: Damaschke, Nathan A., Gawdzik, Joseph, Avilla, Mele, Yang, Bing, Svaren, John, Roopra, Avtar, Luo, Jian-Hua, Yu, Yan P., Keles, Sunduz, Jarrard, David F.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7275597/
https://ncbi.nlm.nih.gov/pubmed/32503656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-020-00869-7
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