Harnessing regulatory T cell neuroprotective activities for treatment of neurodegenerative disorders

ABSTRACT: Emerging evidence demonstrates that adaptive immunity influences the pathobiology of neurodegenerative disorders. Misfolded aggregated self-proteins can break immune tolerance leading to the induction of autoreactive effector T cells (Teffs) with associated decreases in anti-inflammatory n...

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Veröffentlicht in:Mol Neurodegener
Hauptverfasser: Machhi, Jatin, Kevadiya, Bhavesh D., Muhammad, Ijaz Khan, Herskovitz, Jonathan, Olson, Katherine E., Mosley, R. Lee, Gendelman, Howard E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2020
Schlagworte:
Review
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7275301/
https://ncbi.nlm.nih.gov/pubmed/32503641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-020-00375-7
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