Mode of action of teixobactins in cellular membranes

The natural antibiotic teixobactin kills pathogenic bacteria without detectable resistance. The difficult synthesis and unfavourable solubility of teixobactin require modifications, yet insufficient knowledge on its binding mode impedes the hunt for superior analogues. Thus far, teixobactins are ass...

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Publicat a:Nat Commun
Autors principals: Shukla, Rhythm, Medeiros-Silva, João, Parmar, Anish, Vermeulen, Bram J. A., Das, Sanjit, Paioni, Alessandra Lucini, Jekhmane, Shehrazade, Lorent, Joseph, Bonvin, Alexandre M. J. J., Baldus, Marc, Lelli, Moreno, Veldhuizen, Edwin J. A., Breukink, Eefjan, Singh, Ishwar, Weingarth, Markus
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7275090/
https://ncbi.nlm.nih.gov/pubmed/32503964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-16600-2
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