Teixobactin analogues reveal enduracididine to be non-essential for highly potent antibacterial activity and lipid II binding

Teixobactin is a highly promising antibacterial depsipeptide consisting of four d-amino acids and a rare l-allo-enduracididine amino acid. l-allo-Enduracididine is reported to be important for the highly potent antibacterial activity of teixobactin. However, it is also a key limiting factor in the d...

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Detalhes bibliográficos
Publicado no:Chem Sci
Main Authors: Parmar, Anish, Iyer, Abhishek, Prior, Stephen H., Lloyd, Daniel G., Leng Goh, Eunice Tze, Vincent, Charlotte S., Palmai-Pallag, Timea, Bachrati, Csanad Z., Breukink, Eefjan, Madder, Annemieke, Lakshminarayanan, Rajamani, Taylor, Edward J., Singh, Ishwar
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2017
Assuntos:
Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5855875/
https://ncbi.nlm.nih.gov/pubmed/29568465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7sc03241b
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